Combining the liver model with phylogenetic footprinting for selected sequences. The sequence similarity between human and rodent sequences as determined with DBA (Jareborg et al. 1999) is shown as a solid black line. The position-dependent LMM score of the human sequence centered with respect to a 200-bp window is shown as a broken gray line. Documented regulatory regions, depicted by triangles, are characterized by strong score for both DBA and LMM. Boxes show annotated exons that possess a high level of cross species conservation, reflected by a high DBA score. The position with respect to the human sequence is shown along the abscissa. Fig. 4A addresses CYP7A1 (human accession L13460, rat U01962). Fig. 4B addresses IGF1 (human S85346[identical with M12659], mouse Y18062).
