Mapping of Quantitative Trait Loci with Knockout/Congenic Strains

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 2.
Figure 2.

Open field performance of inbred and knockout/congenic mouse strains. The knockout mouse strains tested included B6-Il10tm1Cgn (N10F14), B6-Fmr1tm1Cgr (N9), B6-Apoetm1Unc (N10F19), B6-Selptm1Bay (N10F14), B6-Lcktm1Mak (N12), B6-Cd4tm1Knw (N10F8), B6-Il6tm1Kopf (N11F7), and B6-Cd28tm1Mak (N12F8). Knockout mice are all on a B6 background and in at least the N9 generation of backcrossing. They are indicated by the name of the ablated target gene. Twelve male mice of each strain were tested. Results are shown + s.e.m. There was a significant effect of strain (F8,99 = 4.236,P<.001). Fisher's posthoc tests were then used to make pairwise comparisons. Single asterisks indicate P<0.05; double asterisks indicate P<0.01 in ANOVA analysis usingSTATVIEW.

This Article

  1. Genome Res. 11: 1549-1552

Preprint Server



Current Issue

  1. January 2026, 36 (1)
  1. Current Issue
  1. Alert me to new issues of Genome Research