Figure 3.
Suppression of signals of repetitve sequences with human Cot-1 fraction. The variant detection arrays (VDAs) were hybridized with enriched targets without adding Cot-1 (A) and with 30 ng/μL human Cot-1 fraction (B). The bright signals at thetop of the image are attributable to unique sequences that were enriched. The dark region below had little intensity because the sequences were not enriched. The lower portion shows the cross-hybridization from repetitive sequences (A) that was diminished by adding human Cot-1 DNA.
