Flexible Use of High-Density Oligonucleotide Arrays for Single-Nucleotide Polymorphism Discovery and Validation

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Figure 2.
Figure 2.

SNP screening with variant detection arrays (VDAs). (A) The whole image of 40 pM targets hybridized with VDA. (B) An expanded view of a portion of A. (C) The same region of image as in B except that the chip was hybridized with enriched targets. (D) A single nucleotide polymorphism (SNP) detected and confirmed by alternative sample preparation. Fromtop to bottom, the wild type (base T at thecenter), heterozygous SNP (bases C and T at thecenter), and homozygous mutation (base C at thecenter) are shown.

This Article

  1. Published in Advance July 12, 2001, doi: 10.1101/gr.171101 Genome Res. 11: 1418-1424

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