Changes in Gene Expression Associated with Developmental Arrest and Longevity in Caenorhabditis elegans

Table 2.

Expression of Genes Implicated Previously in Lifespan and Dauer

Gene Dauer tags Mixed tags Significance
C15F1.b (sod-1) superoxide dismutase (Giglio et al. 1994) 60 59 0.96
F55H2.1 (sod-4) superoxide dismutase (Fujii et al. 1998) 26 5 0
C08A9.1 (sod-3) Manganese superoxide dismutase (Honda and Honda 1999) 18 0 0
ZK430.1 superoxide dismutase 0 0 NA
T24H7.1 prohibitin-like (Coates et al. 1997) 3 1 0.39
ZC395.2 (clk-1) (Lakowski and Hekimi 1996) 8 10 0.60
C12D8.10a/b (akt-1) protein kinase (Paradis and Ruvkun 1998) 28 6 0
B0334.8 (daf-23,age-1) phosphatidylinositol-3-OH kinase (Larsen et al. 1995) 6 3 0.33
C11E4.1 glutathione peroxidase (Vanfleteren 1993) 68 15 0
C11E4.2 glutathione peroxidase (Vanfleteren 1993) 17 2 0
R03G5.5 glutathione peroxidase (Vanfleteren 1993) 2 0 0.09
F26E4.12 glutathione peroxidase (Vanfleteren 1993) 2 1 0.57
Y54G11A.6 catalase (ctl-1) (Vanfleteren 1993; Taub et al. 1999) 15 7 0.10
Y54G11A.5a/b peroxisomal catalase (Vanfleteren 1993) 11 7 0.37
ZC395.6 (gro-1) (Hodgkin and Doniach 1997) 0 4 0.02
R11A8.4 (sir-2) Yeast regulatory protein SIR2-like (Tissenbaum and Guarente 2001) 2 3 0.63
H42K12.1 (pdk-1) Akt/PKB kinase like (Paradis et al. 1999) 0 0 NA
Y55D5A.b (daf-2) Insulin receptor-like (Kimura et al. 1997) 1 1 0.98
T28B8.2 (ins-1) Insulin-like (Pierce et al. 2001) 6 1 0.05
R13H8.1 (daf-16) HNF-3/forkhead family member (Lin et al. 1997) NA
R10H10.2 (spe-26) (Varkey et al. 1995) 0 0 NA
C08H9.5 (cold-1) Protein tyrosine kinase (Rikke et al. 2000) 4 1 0.17
F29C4.1 (daf-1) Protein kinase (Georgi et al. 1990) 3 3 0.97
F25E2.5 (daf-3) Smad protein (Patterson et al. 1997) 3 5 0.45
C05D2.1a (daf-4) Receptor protein kinase (Estevez et al. 1993) 1 3 0.29
B0412.2 (daf-7) TGF-β (Ren et al. 1996) 2 4 0.39
B0240.3 (daf-11) transmembrane guanylyl cyclase (Birnby et al. 2000) 0 6 0
T07A9.6 (daf-18) PTEN homolog (Ogg and Ruvkun 1998) 1 8 0.01
F33H1.1 (daf-19) RFX-type transcription factor (Swoboda et al. 2000) NA
  • Significance indicates the probability of the null hypothesis that no difference exists between the expression in both dauer and mixed stage populations, determined by the G test (Sokal and Rohlf 1995).

  • Indicates genes for which SAGE tags could not unambiguously identify the transcript profile.

This Article

  1. Genome Res. 11: 1346-1352

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