Top 25 Genes More Highly Expressed in ALL Than in AML
| Gene description | Probe | Difference | S.E. | Z-score | P-value | Fold diff | t-test | t rank | ut-test | ut rank | W. r.s. | W rank8 |
| C-myb | U22376 | −3183.79 | 429.30 | −7.42 | <0.0001 | 5.39 | 0.1827 | 7 | <0.0001 | 1 | 0.0371 | 2 |
| p48 | X74262 | −1115.97 | 152.35 | −7.33 | <0.0001 | 5.24 | 0.2268 | 8 | <0.0001 | 2 | 0.0911 | 6 |
| Proteasome iota chain | X59417 | −3331.23 | 481.79 | −6.91 | <0.0001 | 3.94 | 0.3777 | 12 | <0.0001 | 3 | 0.3756 | 23 |
| Myosin light chain (alkali) | M31211 | −408.99 | 59.50 | −6.87 | <0.0001 | 3.57 | 0.1584 | 5 | <0.0001 | 4 | 0.2854 | 19 |
| Macmarcks | HG1612– | −2512.37 | 372.76 | −6.74 | <0.0001 | 2.87 | 0.2555 | 9 | <0.0001 | 5 | 0.0432 | 3 |
| HT1612 | ||||||||||||
| Transcription factor 3 (E2A) | M65214 | −471.84 | 70.04 | −6.74 | <0.0001 | 1.56 | 0.1759 | 6 | <0.0001 | 6 | 0.8348 | >59 |
| Inducible protein | L47738 | −1055.39 | 159.50 | −6.62 | <0.0001 | 6.64 | 0.7782 | 23 | 0.0012 | 7 | 0.0584 | 5 |
| MB-1 (CD79b) | U05259 | −3399.02 | 523.02 | −6.50 | <0.0001 | 12.26 | 1.0000 | >28 | 0.0016 | 8 | 1.0000 | >59 |
| Crystallin zeta (quinone reductase) | L13278 | −118.93 | 18.33 | −6.49 | <0.0001 | 27.36 | 0.4366 | 16 | 0.0018 | 9 | 0.5629 | 37 |
| Transcriptional activator hSNF2b | D26156 | −766.23 | 118.24 | −6.48 | <0.0001 | 2.35 | 0.3940 | 13 | 0.0019 | 10 | 0.4304 | 18 |
| Acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain | M91432 | −669.68 | 104.25 | −6.42 | <0.0001 | 4.29 | 1.0000 | >28 | 0.0020 | 11 | 0.1626 | 11 |
| Oncoprotein 18 | M31303 | −2013.15 | 314.83 | −6.39 | <0.0001 | 2.12 | 0.0309 | 2 | 0.0029 | 13 | 0.1874 | 13 |
| Thymopoietin beta | U09087 | −125.08 | 19.56 | −6.39 | <0.0001 | 3.43 | 0.8446 | 26 | 0.0023 | 12 | 0.3277 | 22 |
| Cyclin D3 | M92287 | −3025.10 | 484.75 | −6.24 | <0.0001 | 3.86 | 1.0000 | >28 | 0.0035 | 14 | 0.0911 | 7 |
| Serine kinase SRPK2 | U88666 | −105.40 | 16.98 | −6.21 | <0.0001 | 2.08 | 0.4101 | 15 | 0.0044 | 17 | 0.7333 | 44 |
| Transcription factor 3 (E2A) | M31523 | −1044.46 | 169.32 | −6.17 | <0.0001 | 4.38 | 1.0000 | >28 | 0.0043 | 15 | 0.0371 | 1 |
| Adenosine triphosphatase, calcium | Z69881 | −1809.52 | 293.38 | −6.17 | <0.0001 | 7.26 | 1.0000 | >28 | 0.0043 | 16 | 0.6423 | 39 |
| IEF SSP 9502 | L07758 | −278.58 | 45.28 | −6.15 | <0.0001 | 2.06 | 0.5292 | 19 | 0.0052 | 18 | 0.2483 | 18 |
| Minichromosome maintenance deficient 3 | D38073 | −598.54 | 97.78 | −6.12 | <0.0001 | 2.85 | 0.8160 | 24 | 0.0055 | 20 | 0.4921 | 29 |
| Cytoplasmic dynein light chain 1 | U32944 | −1349.78 | 221.68 | −6.09 | <0.0001 | 5.16 | 1.0000 | >28 | 0.0054 | 19 | 1.0000 | >59 |
| Aldehyde reductase 1 | X15414 | −818.57 | 135.98 | −6.02 | <0.0001 | 2.26 | 0.0312 | 20 | 0.0090 | 24 | 0.4305 | 27 |
| Spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) | J05243 | −732.24 | 122.22 | −5.99 | <0.0001 | 6.26 | 1.0000 | >28 | 0.0078 | 21 | 0.1626 | 12 |
| Rabaptin-5 | Y08612 | −220.83 | 36.90 | −5.98 | <0.0001 | 2.20 | 1.0000 | >28 | 0.0079 | 23 | 1.0000 | >59 |
| Topoisomerase (DNA) II beta | Z15115 | −2927.58 | 490.37 | −5.97 | <0.0001 | 3.20 | 1.0000 | >28 | 0.0079 | 22 | 0.0678 | 5 |
| HKR-T1 | S50223 | −287.95 | 48.38 | −5.95 | <0.0001 | 5.68 | 0.5208 | 18 | 0.0097 | 25 | 1.0000 | >59 |
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Dataset from Golub et al. (1999).
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↵ P-value computed from Z-score using a modified Bonferroni's correction.
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↵ P-value obtained from t-test with equivalent variances using a modified Bonferroni's correction.
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↵Relative ranking by significance values obtained from t-test with equivalent variances. >28 indicates that the gene was not ranked because the P-value was 1.0.
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↵ P-value obtained from t-test with unequal variances using a modified Bonferroni's correction.
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↵Relative ranking by significance values obtained from t-test with unequal variances.
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↵ P-value obtained from Wilcoxon rank sum using a modified Bonferroni's correction.
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↵Relative ranking by Wilcoxon significance values. >59 indicates that the gene was not ranked because the P-value was 1.0.
