Table 1.
List of Human ABC Genes, Chromosomal Location, and Function
| Gene | Alias | Location | Subfamily | Expression | Function |
| ABCA1 | ABC1 | 9q31.1 | ABC1 | Ubiquitous | Cholesterol efflux onto HDL |
| ABCA2 | ABC2 | 9q34 | ABC1 | Brain | Drug resistance |
| ABCA3 | ABC3, ABCC | 16p13.3 | ABC1 | Lung | |
| ABCA4 | ABCR | 1p22.1-p21 | ABC1 | Photoreceptors | N-retinylidene-PE efflux |
| ABCA5 | 17q24 | ABC1 | Muscle, heart, testes | ||
| ABCA6 | 17q24 | ABC1 | Liver | ||
| ABCA7 | 19p13.3 | ABC1 | Spleen, thymus | ||
| ABCA8 | 17q24 | ABC1 | Ovary | ||
| ABCA9 | 17q24 | ABC1 | Heart | ||
| ABCA10 | 17q24 | ABC1 | Muscle, heart | ||
| ABCA12 | 2q34 | ABC1 | Stomach | ||
| ABCA13 | 7p11-q11 | ABC1 | Low in all tissues | ||
| ABCB1 | PGY1, MDR | 7p21 | MDR | Adrenal, kidney, brain | Multidrug resistance |
| ABCB2 | TAP1 | 6p21 | MDR | All cells | Peptide transport |
| ABCB3 | TAP2 | 6p21 | MDR | All cells | Peptide transport |
| ABCB4 | PGY3 | 7q21.1 | MDR | Liver | PC transport |
| ABCB5 | 7p14 | MDR | Ubiquitous | ||
| ABCB6 | MTABC3 | 2q36 | MDR | Mitochondria | Iron transport |
| ABCB7 | ABC7 | Xq12-q13 | MDR | Mitochondria | Fe/S cluster transport |
| ABCB8 | MABC1 | 7q36 | MDR | Mitochondria | |
| ABCB9 | 12q24 | MDR | Heart, brain | ||
| ABCB10 | MTABC2 | 1q42 | MDR | Mitochondria | |
| ABCB11 | SPGP | 2q24 | MDR | Liver | Bile salt transport |
| ABCC1 | MRP1 | 16p13.1 | CF/MRP | Lung, testes, PBMC | Drug resistance |
| ABCC2 | MRP2 | 10q24 | CF/MRP | Liver | Organic anion efflux |
| ABCC3 | MRP3 | 17q21.3 | CF/MRP | Lung, intestine, liver | Drug resistance |
| ABCC4 | MRP4 | 13q32 | CF/MRP | Prostate | Nucleoside transport |
| ABCC5 | MRP5 | 3q27 | CF/MRP | Ubiquitous | Nucleoside transport |
| ABCC6 | MRP6 | 16p13.1 | CF/MRP | Kidney, liver | |
| CFTR | ABCC7 | 7q31.2 | CF/MRP | Exocrine tissue | Chloride ion channel |
| ABCC8 | SUR | 11p15.1 | CF/MRP | Pancreas | Sulfonylurea receptor |
| ABCC9 | SUR2 | 12p12.1 | CF/MRP | Heart, muscle | |
| ABCC10 | MRP7 | 6p21 | CF/MRP | Low in all tissues | |
| ABCC11 | MRP8 | 16q11-q12 | CF/MRP | Low in all tissues | |
| ABCC12 | MRP9 | 16q11-q12 | CF/MRP | Low in all tissues | |
| ABCD1 | ALD | Xq28 | ALD | Peroxisomes | VLCFA transport regulation |
| ABCD2 | ALDL1, ALDR | 12q11-q12 | ALD | Peroxisomes | |
| ABCD3 | PXMP1, PMP70 | 1p22-p21 | ALD | Peroxisomes | |
| ABCD4 | PMP69, P70R | 14q24.3 | ALD | Peroxisomes | |
| ABCE1 | OABP, RNS41 | 4q31 | OABP | Ovary, testes, spleen | Oligoadenylate binding protein |
| ABCF1 | ABC50 | 6p21.33 | GCN20 | Ubiquitous | |
| ABCF2 | 7q36 | GCN20 | Ubiquitous | ||
| ABCF3 | 3q25 | GCN20 | Ubiquitous | ||
| ABCG1 | ABC8, White | 21q22.3 | White | Ubiquitous | Cholesterol transport? |
| ABCG2 | ABCP, MXR, BCRP | 4q22 | White | Placenta, intestine | Toxin efflux, drug resistance |
| ABCG4 | White2 | 11q23 | White | Liver | |
| ABCG5 | White3 | 2p21 | White | Liver, intestine | Sterol transport |
| ABCG8 | 2p21 | White | Liver, intestine | Sterol transport |
