Genome-Wide Epistatic Interaction Analysis Reveals Complex Genetic Determinants of Circadian Behavior in Mice

Table 4.

Multiple Regression Model of Circadian Phenotypes

Trait Source DF Adj SS F P
Period D4Mit178 2 2.49 12.13 1.10E-05
D5Mit188 2 1.64 7.97 4.80E-04
D12Mit236 2 1.25 6.07 3.00E-03
D5Mit188*D12Mit236 4 1.31 3.18 1.50E-02
Error 181 18.60
Total 191 26.52
Phenotype explained 30.00%
Phase D7Mit30 2 30.94 5.84 3.50E-03
D8Mit13 2 6.01 1.14 3.20E-01
D12Mit81 2 58.43 11.04 3.00E-05
D12Mit263 2 27.99 5.29 5.90E-03
D18Mit17 2 24.95 4.71 1.00E-02
D8Mit13*D12Mit263 4 46.99 4.44 1.90E-03
D7Mit30*D12Mit81 4 23.61 2.23 6.80E-02
Error 177 468.46
Total 195 739.86
Phenotype explained 37.00%
Amplitude Sex 1 294.84 11.97 6.70E-04
D1Mit33 2 170.55 3.46 3.30E-02
D4Mit27 2 303.11 6.15 2.60E-03
D1Mit33*D4Mit27 4 777.93 7.89 6.80E-06
Error 186 4582.62
Total 195 6197.05
Phenotype explained 25.80%
Activity (Female only) D16Mit106 2 7.81 2.10 1.28E-01
DXMit27 1 0.09 0.05 8.26E-01
D16Mit106*DXMit27 2 32.22 8.68 3.50E-04
Error 91 168.94
Total 96 209.05
Phenotype explained 19.00%
Dissociation D12Mit251 2 16.47 6.44 2.00E-03
D15Mit28 2 17.99 7.01 1.10E-03
D12Mit251*D15Mit28 4 44.72 8.74 1.74E-06
Error 187 239.11
Total 195 298.75
Phenotype explained 20.00%

This Article

  1. Genome Res. 11: 959-980

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