Genome-Wide Epistatic Interaction Analysis Reveals Complex Genetic Determinants of Circadian Behavior in Mice

Table 3.

Summary of Significant Marker Pair from Genome-Wide Interaction Analysis

Trait Marker1 Marker2 F-all F-int F-add1 F-add2
Period D4Mit178 D5Mit188 6.57 1.78 13.50 7.81
D4Mit178 D12Mit236 5.54 1.36 12.03 5.12
D5Mit98 D12Mit236 5.73 3.06 9.03 7.00
Phase D7Mit30 D12Mit81 5.77 2.65 7.50 9.91
D8Mit13 D12Mit263 5.23 5.89 0.59 7.11
D12Mit81 D18Mit17 6.21 2.43 11.89 9.49
D12Mit195 D18Mit17 5.47 2.22 9.65 6.16
Amplitude D1Mit33 D4Mit27 6.46 6.88 1.81 8.81
Activity D16Mit106 DXMit27 5.04 7.23 0.00 5.00
Dissociation D12Mit251 D15Mit28 5.90 8.80 1.17 4.56
  • Significance of F-all is assessed by permutation analysis. See text for threshold values.

  • The alpha = 0.01 critical value for F-int is 3.42.

  • The alpha = 0.01 critical value for F-add1 and F-add2 is 4.72.

This Article

  1. Genome Res. 11: 959-980

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