Genome-Wide Epistatic Interaction Analysis Reveals Complex Genetic Determinants of Circadian Behavior in Mice

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 2.
Figure 2.

Frequency histogram of phenotypic measures for each generation. For each panel, the distribution histograms are presented in the following order from top to bottom: C57BL/6J, BALB/cJ, (BALB/cJ X C57BL/6J)F1, (BALB/cJ X C57BL/6J)F2.(A) The distribution of free-running period in constant darkness, as determined by χ2periodogram analysis of 20 days. Data is presented in 1/10 h bins. (B) The phase angle of entrainment, relative to the time of lights off. Values are plotted in 1/2 h bins, with positive values indicating activity onset preceding lights-off, and negative values indicate activity onset following lights-off. (C) The distributions of amplitude of circadian rhythmicity in constant darkness. Amplitude is estimated from the Fast Fourier Transform of 15 days' data in constant darkness. The total power from 0 to 1 cycles/hour is normalized to a value of 1.0, and the resultant relative power of the peak in the circadian range (18–30 h period) is taken as a measure of circadian amplitude. (D) The distributions of mean total daily activity levels. Values are individual mean numbers of wheel revolutions/24 h for 15 d in constant darkness.

This Article

  1. Genome Res. 11: 959-980

Preprint Server