Computational Inference of Homologous Gene Structures in the Human Genome

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Figure 1.Figure 1.
Figure 1.

Examples of GenomeScan predictions.GenomeScan was run with GenomeScript, using similarity to available mouse proteins from GenPept Release 118 (June 2000). Two examples are shown. Exons and genes on the forward strand are shown above the sequence line; reverse strand exons and genes are shown below the sequence line. BLASTX hits with P < 0.05 are shown as green blocks above or below the sequence line, according to the reading frame/strand indicated by BLAST. (A) GenBank locus HUMBRCA1 (accession no. L78833). (B) GenBank locus HSU52111 (accession no. U52111). Only the first 140 kbp (of 153 kbp) of the sequence is shown for clarity. The extra predicted exons upstream of PLEXR and SK and the extra predicted gene at ∼118 kb are supported by several human ESTs (accession nos. AW663636, AA514687, AW071821, and others).

This Article

  1. Genome Res. 11: 803-816

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