The Human Genome Sequence Expedition: Views from the “Base Camp”

Features of the Human Genome—A Scorecard

Genetic maps
 Total male length 2730 cM
 Total female length 4250 cM
 No. genetic markers ∼8000
 No. recombination cold spots 19 regions
 No. recombination hot spots 12 regions
Physical maps
 No. mapped BAC clones 372,264
 Depth 20-fold
Sequence
 Estimated genome size
  Human Genome Project 3200 Mb (2900 Mb  euchromatic)
  Celera Genomics 2910 Mb
 Total coverage in working    draft sequence ∼90%
 GC content ∼40% (range 30–65%)
 Repeats ∼44%
 Coding ∼1.5%
 Unique, noncoding ∼54.5%
 Estimated no. genes
  Human Genome Project 32,000
  Celera Genomics 39,114
 Average gene size 27 kb
 No. protein families 1695
  • Derived from information provided in the International Human Genome Sequencing Consortium (2001) and Venter et al. (2001).

This Article

  1. Genome Res. 11: 645-651

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