Multiple sequence alignment of cDNA DKFZp434P211 with POM121-related 1 (accession no. D87002) and sequences from chromosome 22 demonstrate the presence of a cluster of POM121-related genes. The individual genomic sequences were named after the start of the first exon relative to the cDNA: The open reading frame (ORF) was defined according to the predicted protein of the cDNA and of POM121-related 1. Genes located on the plus and minus strands of chromosome 22 are indicated with + and −, respectively. The cDNA sequence of DKFZp434P211 was taken as reference; identical residues in other sequences are indicated with a dot, residues deviating from the consensus are printed. Asterisks (*) indicate stop codons. The genomic sequences 2850458 and 2871777 are in italics because these copies deviate from the other copies by a premature stop or frame shifts and a large insertion, respectively, and are probably not expressed. In these two gene copies the initiator ATG is mutated. Dashes (-) were inserted by the software (CLUSTAL) to optimize the alignment.
