Sequence analysis of the NICE-5 and NICE-2 gene products. cDNA clones 11591 8 (NICE-5) (top) and 1192j18 (NICE-2) (bottom) contain the 3′-termini of the corresponding transcripts. Overlapping ESTsAA287174 and AA641342 were used to extend the NICE-5 sequence. Sequence information derived from the respective clones is represented by open boxes; broken line boxes indicate lacking sequences as deduced from the approximate size of the entire mRNA, which was determined by Northern hybridization. The ORF of NICE-5 (shaded gray) is likely to be incomplete. No significant ORF was detected within theNICE-2 sequence. Numbering is relative to the start of the available sequence (+1). In the case of NICE-5, the last nucleotide of the putative coding sequence and the minimum protein size are indicated. The size of the protein resulting from the first initiation methionine codon within the available sequence and the position of the initial adenine (▵) are in parenthesis.
