Identification of Human Epidermal Differentiation Complex (EDC)-Encoded Genes by Subtractive Hybridization of Entire YACs to a Gridded Keratinocyte cDNA Library

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Figure 3.
Figure 3.

Alignment of the cDNA clones 31131 8 and 3162o12 representing two different alleles of the SPRR3 gene. Black boxes indicate divergences in the nucleotide sequences, open boxes indicate divergences in the deduced amino acid sequences that contain 14 (clone 31131 8) and 13 (clone 3162o12) octapeptide repeats (shaded gray), respectively. Among the four mutations within the coding region, only one results in a substituted amino acid residue, with higher homology to the consensus repeat sequence TKVPEPGC of clone 3162o12.

This Article

  1. Genome Res. 11: 341-355

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