Comparative Sequence Analysis of the Imprinted Dlk1–Gtl2 Locus in Three Mammalian Species Reveals Highly Conserved Genomic Elements and Refines Comparison with the Igf2–H19 Region

Table 1.

Contents of Interspersed Repeats

G+C content Sine Line Line1 LTR elements DNA transposon-like elements Unclassified elements Total interspersed repeats
mouse
Dlk1-Gtl2 49.4% 9.6% 3.2% 3.0% 1.6% 0.3% 0.0% 14.7%
lgf2-H19 51.4% 1.8% 0.9% 0.7% 2.0% 0.1% 0.0% 4.8%
genome 46–50% 14.4% n.d. 3.4% 9.9% n.d. n.d 28.9%
50–54% 16.5% n.d. 1.4% 3.6% n.d. n.d. 20.3%
human
DLK1-GTL2 51.4% 13.5% 12.6% 11.6% 7.4% 2.3% 0.0% 35.8%
lGF2-H19 59.5% 3.6% 4.4% 3.4% 3.1% 1.2% 0.0% 12.3%
autosomes 50–54% 25.5% n.d. 4.8% 4.7% 1.8% n.d. 41%
>54% 20.1% n.d. 3.0% 2.9% 1.2% n.d. 31%
X chromosome 50–54% 24.9% n.d. 6.1% 2.7% 1.1% n.d. 38%
>54% 14.8% n.d. 5.3% 2.8% 1.0% n.d. 26%
sheep
Dlk1-Gtl2 53.7% 5.5% 12.0% 20.5% 20.5% 20.5% 20.5% 20.5%
  • Shown are summaries for the interspersed repeats that were identified using RepeatMasker( http://ftp.genome.washington.edu/index.html ) for the analyzed sequences. The average values for human autosomal and X chromosome linked sequences and mouse genome-wide sequences were taken from Smit (1999). Separate values for mouse autosomes and X chromosome were not available. Because the content of interspersed repeats is related to the G+C content, the values are given for sequences that show G+C contents similar to the imprinted regions analyzed here.

  • Sum of the values for Alu and Mir elements; n.d., not defined.

This Article

  1. Genome Res. 11: 2085-2094

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