Identification of Wound Healing/Regeneration Quantitative Trait Loci (QTL) at Multiple Time Points that Explain Seventy Percent of Variance in (MRL/MpJ and SJL/J) Mice F2 Population

Table 1.

Location of Sth QTL as Determined from the F2 Intercross

QTL Microsatelite marker cM LOD score (% explained) Avg % Expl
Day 15 Day 21 Day 25
Sth1 D1MIT334 49.2 6.95 (5.8) 6.82 (5.6) 7.06 (5.8) 6.94
Sth2 D3MIT217 43.7 5.86 (7.0) 6.18 (7.6) 5.38 (6.5) 7.0
Sth3 D4MIT214 21.9 6.48 (5.7) 7.26 (6.4) 6.14 (5.4) 6.6
Sth4 D4MIT31 50.3 5.30 (5.5) 6.82 (6.2) 6.50 (6.0) 6.2
Sth5 D6MIT261 29.5 3.60 (3.2) 4.50 (4.0) 4.11 (3.7) 4.07
Sth6 D7MIT220 38.3 3.05 (2.9) (S) 4.36 (4.1) 4.84 (4.8) 4.08
Sth7 D7MIT12 62.3 3.54 (3.1) 3.84 (3.6) 4.26 (3.9) 3.88
Sth8 D9MIT207 31.7 11.99 (10.2) 13.95 (11.8) 14.18 (12.0) 13.54
Sth9 D9MIT270 41.5 12.99 (10.8) 15.60 (13.0) 16.11 (13.3) 14.90
Sth10 D13MIT228 45.9 2.92 (2.5)(S) 3.03 (2.6)(S) 2.72 (2.4)(S) 2.89
  • The LOD threshold determined by permutation test is ≥3.5 for significant linkage and 2.7 for suggestive linkage (the same as significant level of 1% and 5%, respectively) for a chromosome length of 100 cM.

  • QTLs identified previously by McBrearty et al. (1998).

  • Avg % Exp = Average (days 15, 21, and 25) percent variance explained F2 mice (70%).

This Article

  1. Genome Res. 11: 2027-2033

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