Table 4.
Requirement for Manual Validation of Comparative Results
| Concept | DIAN /Role node number | Present in DIAN and GO | DIAN only | GO only | Reported type I variation | Effective number of type I assignments | Effective rate of type I variation |
| Cytoskeletal | 3.1 | 30 | 19 | 16 | 0.29 | 4 | 0.06 |
| Nucleotide | 6.5 | 6 | 25 | 11 | 0.60 | 3 | 0.05 |
| Sugar/glycolysis | 6.7 | 0 | 35 | 8 | 0.81 | 3 | 0.07 |
| RNA polymerases | 5.1.1 | 0 | 4 | 0 | 1.00 | 4 | 0.00 |
| RNA processing | 5.1.2 | 4 | 9 | 10 | 0.39 | 1 | 0.04 |
| Transcription factors | 5.1.3 | 142 | 124 | 98 | 0.34 | 0 | 0.00** |
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Type I variation here refers to those assignments made byDIAN but not in the reference ontology implementation system (GO system). Manual validation results show that Type I variation (DIAN-only assignments) cannot simple be treated as Type I error in a strict statistical sense.
