Table 1.
Example Queries that Cannot be Resolved Accurately by Conventional Querying Systems
| Case type | Source record: DIAN system annotation | |||||
| Identifier | EGAD celluar role | Protein function | Enzyme classification | DoubleTwist biological role | Structure (SCOP) | |
| Annotation | ||||||
| Case 1: Novel gene with no predicted function | UniGene Hs. 104305 | •cell/organism defense•homeostasis•apoptosis•cell division•apoptosis | None | None | •Non-immune cell defense•Apoptosis | •All alpha proteins•DEATH domain•DEATH domain•DEATH domain |
| None | ||||||
| Case 2: Hypothetical gene with predicted function | SWISS-PROT P39959 | •gene/protein expression•RNA synthesis•transcription factors | •DNA or RNA associated proteins | None | •Genome structure and Gene expression•Transcription factors | •Small proteins•Classic zinc finger, C2H2•Classic zinc finger, C2H2•Classic zinc finger, C2H2 |
| Putative Zinc Protein | ||||||
| Case 3: Known gene with novel predicted function | UniGene Hs. 2157 | •cell division•apoptosis | •Enzymes•Transferase•Post-translational modifications | •Transferases | •Non-immune cell defense•Apoptosis | •All beta proteins•PH domain-like•PH domain-like•Enabled/VASP homology 1 domain (EVH1 domain) |
| Wiskott-Aldrich syndrome proteinOMIM: 30100 SWISS-PROT: P42768 | ||||||
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Three illustrative cases of records that cannot be returned by conventional keyword-based querying systems but that were returned byDIAN are described here.
