Whole Genome Comparison of Campylobacter jejuni Human Isolates Using a Low-Cost Microarray Reveals Extensive Genetic Diversity

Table 3.

Divergence in the 42.6 kb NCTC 11168 Capsule Biosynthetic Locus in theCampylobacter jejuni Strains Studied

Gene name Function Clone content (%) Phase variable 81116 81-176 X G1 P1 P2 P3 P4 PHLS 01 PHLS 02 PHLS 03
Cj1413 kpsS Cj1413 (67) + + + + + + + + + + +
Cj1414 kpsC Cj1413(16) + + + + + + + + + + +
Cj1414 (50)
Cj1415 cysC Cj1414(20) (+) + + + + + + + + + +
Cj1415 (100)
Cj1416 (17)
Cj1416 sugar Cj1416(82) + + + + + + + + + + +
nucleotidyltransferase
Cj1417 GMP synthetase Cj1416(22) + + + + + + + + + + +
Cj1417 (98)
Cj1418 phosphoenolpyruvate Cj1418(39) + + + + + + + + + + +
synthase
Cj1419 methyltransferase Cj1418(9) + + + + + + + + + + +
Cj1419 (77)
Cj1420 unknown Cj1420(73) √ + + + + + + + (+) + + +
Cj1421 sugar transferase Cj1421(33) √ (+) + + + + + + (+) + + +
Cj1422 sugar transferase Cj1422(89) √ − + − + + + (+) − + + +
Cj1423 sugar-phosphate Cj1423 (100) − (+) (+) + + + (+) (+) + (+) +
nucleotidyltransferase Cj1424 (100)  
Cj1425(3)  
Cj1424 gmhA2 Cj1423(22) + + + + + + + + + + +
Cj1424 (100)
Cj1425 (4)
Cj1425 galactose kinase Cj1424(22) − + (+) − − + + + + + +
Cj1425(100)      
Cj1426(20)      
Cj1426 unknown Cj1425(2) √ − + − − − + − (+) + + +
Cj1426(100)          
Cj1427(46)          
Cj1427 sugar-nucleotide Cj1427(75) − + − + + + (+) + + + +
epimerase/dehydratase    
Cj1428 fucose synthetase Cj1427(28) − (+) − + − + − − + + +
Cj1428(100)          
Cj1429(6)          
Cj1429 unknown Cj1428(14) √ − + − + − + − − + + +
Cj1429(100)          
Cj1430(42)          
Cj1430 nucleotide-sugar Cj1429(29) + + + + + + + + + + +
epimerase/dehydratase Cj1430(100)
Cj1431(7)
Cj1431 glycosyltransferase Cj1431(43) − − − − + + − − + + +
Cj1432 glycosyltransferase Cj1432(45) − − − − − + − − + + +
Cj1433 unknown Cj1432(2) √ − − − + + + − − + + +
Cj1433(71)          
Cj1434 galactosyltransferase Cj1434(55) − + − + + + (+) − + + +
Cj1435 phosphoserine Cj1435(100) (+) + + + + + (+) + + + +
phosphatase Cj1436(4)
Cj1436 aminotransferase Cj1436(89) − + − + + + (+) (+) + + +
Cj1437 aminotransferase Cj1437(84) − (+) − + − + − − + + +
Cj1438(2)          
Cj1438 galactosyltransferase Cj1438(42) − (+) − + + + + − + + +
Cj1439 UDP-galactopyranose Cj1439(75) − − − + − + − − + + +
mutase            
Cj1440 galactosyltransferase Cj1440(52) − (+) − + (+) + − − + + +
Cj1441(11)        
Cj1441 kfiD Cj1440(3) − − − − + + − − + + +
Cj1441(73)            
Cj1442 glycosyltransferase Cj1442(47) + + + − + (+) + + (+) + +
Cj1443 kpsF Cj1443(63) + + + + + + + + + + +
Cj1444 kpsD Cj1444(74) + + + + + + + + + + +
Cj1445 kpsE Cj1445(65) + + + + + + + + + + +
Cj1447 (38)
Cj1447 kpsT Cj1445(25) + + + + + (+) + + (+) + +
Cj1447 (100)
Cj1448(13)
Cj1448 kpsM Cj1447(44) + + (+) (+) + + + + + + +
Cj1448 (100)

  • A + or − indicates that the red/green hypridization signal intensity ratio is >0.5 or <0.5, respectively.

  • (+) indicates the possibility that the gene may be absent or highly divergent even though the red/green hybridization signal intensity ratio is >0.5 (see Methods).

  • ↵Putative gene function based on annotation (Parkhill et al. 2000).

  • ↵Genes contain intragenci homopolymeric tracts indicating potential phase variable expression (Parkhill et al. 2000).

  • NB: Cj1446 was originally designated a CDS, but was unannotated in the final genome annotation (Parkhill et al. 2000).

This Article

  1. Published in Advance September 20, 2001, doi: 10.1101/gr.185801 Genome Res. 11: 1706-1715

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