Whole Genome Comparison of Campylobacter jejuni Human Isolates Using a Low-Cost Microarray Reveals Extensive Genetic Diversity

Table 2.

Divergence in Restriction/Modification Systems in Campylobacter jejuni Strains

Gene Function Clone content (%) Phase variable 81116 81-176 X G1 P1 P2 P3 P4 PHLS 01 PHLS 02 PHLS 03
Cj0031 type IIS restriction/ modification enzyme, N-terminal half Cj0031 (31) + + + + + + + + + + +
Cj0032 type IIS restriction/ modification enzyme, C-terminal half Cj0031 (8) Cj0032 (95) + + + (+) + + (+)
Cj0208 DNA modification methylase Cj0207 (1) Cj0208(66) + + + + + + + + + + +
Cj0690 possible restriction/ modification enzyme Cj0690 (34) + + + + (+) + + + + +
Cj0722 DNA methylase Cj0721 (16) Cj0722 (100) Cj0723 (32) + + + + + (+) + + (+) + +
Cj1051 restriction/modification enzyme Cj1051 (25) + + + + + + + (+)
Cj1549 type I restriction enzyme R protein Cj1549(27) + + + + + + + + +
Cj1551 type I restriction enzyme S protein Cj1551 (56) + + + + + + + + +
Cj1553 type I restriction enzyme M protein Cj1553 (39) + + + + + + + + + +
  • A + or − indicates that the red/green hybridization signal intensity ratio is >0.5 or <0.5. respectively.

  • (+) Indicates the possibility that the gene may be absent or highly divergent even though the red/green hybridization signal intensity ratio is > 0.5 (see Methods).

  • Putative gene function based on annotation (Parkhill et al. 2000).

  • Genes contain intragenic homopolymeric tracts indicating potential phase variable expression (Parkhill et al. 2000).

This Article

  1. Genome Res. 11: 1706-1715

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