Partial Deletion of the Bovine ED1 Gene Causes Anhidrotic Ectodermal Dysplasia in Cattle

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Figure 2.
Figure 2.

Alignment of the ectodysplasin 1 (ED1-A1) amino acid sequences of cattle, human, and mouse. The interrupted (Gly-X-Y)19 repeat is underlined. Arrows mark the amino acids 308E and309V that are absent from the ED1-A2 isoform. Note the extremely high-sequence conservation of the proteins in the C-terminal region that harbors the TNF-like signaling domain.

This Article

  1. Published in Advance September 20, 2001, doi: 10.1101/gr.182501 Genome Res. 11: 1699-1705

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