Evolutionarily Conserved Sequences on Human Chromosome 21

Table 2.

Analysis of Chromosome 21 Genes for Overlap with Conserved Elements

Class Analyzed Conserved
Known genes 1.1 94 88
1.2 17 15
Related genes 2.1 9 8
2.2 0
Protein motifs 3.1 8 7
3.2 1 0
 Predicted 4.1 12 6
4.2 16 2
4.3 27 4
  • Class definitions according to Hattori et al. (2000). Briefly: (1.1) genes with 100% identity and known function; (1.2) genes with 100% identity but unknown function; (2.1) genes with similarity to known genes with assigned function; (2.2) genes with similarity to known genes without assigned function; (3.1) genes with similarity to a characterized functional motif; (3.2) genes with similarity to defined region of a known protein without functional association; (4.1) genes predicted based on spliced EST matches and ab initio predicted exons; (4.2) genes predicted on splice EST matches; (4.3) genes predicted on ab initio predicted exons.

  • The number of genes analyzed by cross-species comparison.

  • The number of genes with at least one exon conserved.

This Article

  1. Genome Res. 11: 1651-1659

Preprint Server