Annotation Transfer for Genomics: Measuring Functional Divergence in Multi-Domain Proteins

Table 4.

Superfamilies With the Same Function in Single- and Multi-Domain Proteins as Determined from Their Keyword Combination or First Three Components of Their EC Numbers

Sfam Function Single-domain proteins Multi-domain proteins
SWISS-PROT ID SWISS-PROT function SWISS-PROT ID SWISS-PROT function
1.81.1 E3.2.1 GUNY_ERWCH Endoglucanase (3.2.1.4) AMYG_NEUCR Glucoamylase Precursor (3.2.1.3)
2.66.2 E3.5.1 URE2_YERPS Urease Beta (3.5.1.5) URE1_HELPY Urease Alpha Subunit (3.5.1.5)
3.17.2 E6.3.5 NADE_MYCPN NAD(+) Synthetase (6.3.5.1) GUAA_YEAST GMP Synthase (6.3.5.2)
3.37.1 E3.1.3 PTP2_NPVOP Protein-Tyrosine Phosphatase 2 (3.1.3.48) PTNB_RAT Protein-Tyrosine Phosphatase (3.1.3.48)
3.67.1 E4.2.1 TRPB_VIBPA Tryptophan Synthase (4.2.1.20) TRP_YEAST Tryptophan Synthase (4.2.1.20)
4.19.1 E5.2.1 FKB1_METJA PeptidylprolylCis-Trans Isomerase (5.2.1.8) FKB7_WHEAT 70 Kd Peptidylprolyl Isomerase (5.2.1.8)
4.2.1 E3.2.1 LYCV_BPP2 Lysozyme (3.2.1.17) CHIX_PEA Endochitinase Precursor (3.2.1.14)
4.29.1 85# RS5_ACYKS 30s Ribosomal Protein S5 RS5_TREPA 30s Ribosomal Protein S5
4.52.1 E3.4.24 SNPA_STRCS Extracellular Neutral Protease (3.4.24.–) BMPH_STRPU Collagenase 3 Precursor (3.4.24.–)
4.6.1 E3.5.1 URE3_YERPS Urease Gamma (3.5.1.5) URE1_HELPY Urease Alpha Subunit (3.5.1.5)
5.10.1 E2.7.7 KANU_STAAU Kanamycin Nucleotidyltransferase (2.7.7.–) DPOB_XENLA Dna Polymerase Beta (2.7.7.7)
5.4.1 161# AMPH_ECOLI Penicillin-binding Protein Amph PBPX_STRPN Penicillin-binding Protein 3x Pbp2x

This Article

  1. Genome Res. 11: 1632-1640

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