Table 3.
Most Versatile Superfamily Combinations in Multi-Domain Proteins
| No.func | No.prot | Sfam comb. | Function | SWISS-PROT ID | SWISS-PROT function |
| 29# | THB_RANCA | Thyroid Hormone Receptor Beta | |||
| 10# | HNF4_DROME | Transcription Factor HNF-4 Homolog | |||
| 31#32# | EAR2_MOUSE | V-Erba Related Protein Ear-2 | |||
| 29#30# | ECR_MANSE | Ecdysone Receptor (Ecdysteroid Receptor) | |||
| 22 | 176 | 1.95.1/7.33.1 | 32# | ERBA_AVIER | Erba Oncogene Protein |
| 556#564#35# | NGFI_XENLA | Nerve Growth Factor Induced Protein I-B | |||
| 576# | NR42_HUMAN | Immediate-Early Response Protein Not | |||
| 36# | PPAT_HUMAN | Peroxisome Proliferator Activated Receptor | |||
| 37# | RXTG_CHICK | Retinoic Acid Receptor RXR-Gamma | |||
| 38# | TLL_DROVI | Tailless Protein | |||
| E1.8.2 | DHSU_CHRVI | Sulfide Dehydrogenase (1.8.2.–) | |||
| E1.8.1 | DLDH_ZYMMO | Dihydrolipoamide Dehydrogenase (1.8.1.4) | |||
| 8 | 54 | 3.4.1/4.48.1 | E1.6.4 | TYTR_TRYCR | Trypanothione Reductase (1.6.4.8) (Tr) |
| E1.16.1 | MERA_STRLI | Mercuric Reductase (1.16.1.1) | |||
| E1.6.99 | NAOX_MYCPN | Probable NADH Oxidase (1.6.99.3) (Noxase) | |||
| 19# | ARYB_MANSE | Arylphorin Beta Subunit–(Tobacco Hornworm) | |||
| 20# | CRPI_PERAM | Allergen Cr-Pi Precursor–(American Cockroach) | |||
| 21#427# | HCY_PALVU | Hemocyanin–(European Spiny Lobster) | |||
| 8 | 23 | 1.78.1/2.1.1 | 22# | HEXA_BLADI | Hexamerin Precursor–(Tropical Cockroach) |
| 23# | JSP1_TRINI | Acidic Juvenile Hormonne–Suppressible Protein | |||
| 24# | LSP2_DROME | Larval Serum Protein 2 Precursor (LSP-2) | |||
| 546#25# | SSP1_BOMMO | Sex-Specific Storage–Protein 1 |
-
Note that the combination with the greatest number of different functions is that of 1.95.1 and 7.33.1. Careful examination reveals that all the proteins with this combination are DNA-binding and most of them act as various hormone receptors. In particular, HNF4_DROME and NR42_HUMAN also have transcription activator functions. Note that these two proteins are considerably longer than the others in this group and are not covered completely by structural matches: A large C-terminal and a large N-terminal portion are left uncovered, respectively.
