Table 1.

Functional Distribution of Single-domain, Multi-domain Superfamilies, and Multi-domain Combinations

	Single-domain superfamilies		Multi-domain superfamilies		Multi-domain sfam combinations
	Single function	Multiple function	Single function	Multiple function	Single function	Multiple function
Enzymatic	82	11	135	42	151	16
Nonenzymatic	78	23	56	30	70	27
Both functions	—	15	—	47	—	17
Total	160	55	191	119	221	60

The basic functional distribution of the superfamilies in single- and multi-domain proteins and the functional distribution of multi-domain combinations are shown. The first row lists the number of scop superfamilies that were associated only with enzymatic function in each category. The second row lists the number associated with only nonenzymatic functions, and the third row indicates the number of superfamilies that were associated with both types of function. Altogether, we characterized 160 + 55 = 215 single-domain and 191 + 119 = 310 multi-domain superfamilies, 70 of which overlapped in the two categories.

Annotation Transfer for Genomics: Measuring Functional Divergence in Multi-Domain Proteins