Figure 1.
Schematic illustrating annotation transfer. This figure illustrates the process of annotation transfer for a group of hypothetical TIM barrel proteins. The leftmost panel represents sequence comparisons between idealized barrel domains from a number of organisms. The next panel shows analogous results for structural comparison, and the panel after that, functional comparison. The rightmost panel represents sequence comparisons between idealized multi-domain proteins that match over a single domain, the subject of much of this paper.
