Table 3.

List of Herpesviridae Open Reading Frames with Clear Sequence Conservation in the 19 Genomes

Gene block	Length of conserved sequence	GenBank number (HSV-1)	Gene name (HSV-1)	Function	Functional class
A	750	gi:59530	UL30	DNA polymerase	Rep
A	86	gi:59531	UL31	unknown	Unk
A	436	gi:59533	UL32	virion protein	Str
A	42	gi:59536	UL36	tegument protein	Str
A	285	gi:59539	UL39	ribonucleotide reductase large subunit	Nuc
B	667	gi:59527	UL27	glycoprotein B	Gly
B	599	gi:59528	UL28	transport protein	Str
B	960	gi:59529	UL29	ssDNA binding protein	Rep
C	714	gi:59552	UL52	helicase-primase complex	Rep
C	39	gi:59554	UL54	immediate-early transactivator	Trf
D	63	gi:59522	UL22	glycoprotein H	Gly
D	111	gi:59523	UL24	fusion protein	Str
D	131	gi:59525	UL25	tegument protein	Str
D	185	gi:59526	UL26	capsid protease	Str
E	102	gi:59518	UL18	capsid protein	Str
E	66	gi:59519	UL19	major capsid protein	Str
F	767	gi:59507	UL5	helicase-primase complex	Rep
F	66	gi:59506	UL6	minor capsid protein	Str
F	67	gi:59508	UL7	unknown	Unk
F	283	gi:59510	UL10	glycoprotein M	Gly
F	276	gi:59513	UL12	deoxyribonuclease	Nuc
F	140	gi:59514	UL13	protein kinases	Oth
F	315	gi:59501	UL15₂	DNA packaging	Str
F	143	gi:59501	UL15₁	DNA packaging	Str
F	90	gi:59516	UL16	virion protein	Str
G	218	gi:59503	UL2	uracil-DNA glycosylase	Nuc

↵Gene blocks are regions where the order of genes is conserved of which seven are present in all Herpesviridae genomes (A-G).
↵Conserved sequence regions where sequence homology was clearly detected. These corresponded to a single contigous sequence motif in all cases except for DNA polymerase, in which three different motifs were conserved.
↵Function as derived from GenBank annotations.
↵Functional classes: Rep (replication), Nuc (nucleotide metabolism and DNA repair), Str (structural), Trf (transcription), Gly (glycoprotein), Oth (other), Unk (unknown).

Genomewide Function Conservation and Phylogeny in the Herpesviridae