Table 3.
Germline Transmission of the HCV by HCV+F1 Mice
| Parent | Produced litters HCV+ pups/total no. of pups | Percent germline transmission | ||||||||
| MALE MEIOSIS | ||||||||||
| F1 m 1 | 1/10 | 1/2 | 3/9 | 3/6 | 3/7 | |||||
| F1 m 2 | 6/8 | 2/5 | 1/9 | 1/8 | 5/10 | 4/9 | 4/4 | 1/3 | ||
| F1 m 3 | 1/8 | 0/10 | 1/1 | 0/5 | 0/3 | 0/7 | ||||
| F1 m 4 | 2/6 | 2/7 | 3/6 | 0/1 | 31% | |||||
| F1 m 5 | 1/1 | |||||||||
| F1 m 6 | 8/12 | 3/7 | 4/8 | 2/5 | 2/5 | 1/7 | 0/2 | |||
| F1 m 7 | 0/1 | |||||||||
| F1 m 8 | 0/7 | 1/4 | 0/2 | 0/2 | 1/6 | 1/3 | 2/3 | 0/6 | ||
| FEMALE MEIOSIS | ||||||||||
| F1 f 1 | 6/9 | 7/13 | 3/9 | 4/7 | 6/14 | 5/15 | 7/13 | 6/17 | 2/5 | |
| F1 f 2 | 3/9 | 2/9 | 6/11 | 3/11 | 5/11 | 7/13 | 3/11 | 5/12 | ||
| F1 f 3 | 2/8 | 1/9 | 0/10 | 0/12 | 1/11 | 2/9 | 1/14 | |||
| F1 f 4 | 2/8 | 3/10 | 2/12 | 2/11 | 1/7 | 3/7 | 6/13 | 5/13 | 35% | |
| F1 f 5 | 5/8 | 6/11 | 5/12 | 4/13 | 6/12 | 6/11 | 6/11 | 2/8 | ||
| F1 f 6 | 2/10 | 2/10 | 6/11 | 4/10 | 3/11 | 6/11 | ||||
| F1 f 7 | 1/7 | 2/9 | 5/11 | 2/2 | 2/6 | 5/12 | ||||
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The produced litters of eight male HCV+ mice and seven female HCV+ mice when mated with C57BL/6 mice are shown.
