Efficient Male and Female Germline Transmission of a Human Chromosomal Vector in Mice

Table 2.

Germline Transmission of the HCV by the Two Male Chimeras

Parent Produced litters HCV+ agouti pups/total number ofagouti pups Percent germline transmission
Chimera 1 0/1 0/7 1/7 3/11 3/8 1/6 3/11 22%
Chimera 2 0/2 0/5 5/7 4/7 6/13 3/5 2/8 5/10 3/9 3/5 44%
  • Two male transchromosomal chimeras were mated with C57BL/6 mice. The produced litters are shown.

This Article

  1. Genome Res. 11: 124-136

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