Biased Distribution of Inverted and Direct Alus in the Human Genome: Implications for Insertion, Exclusion, and Genome Stability

Table 1.

Distribution of Alu Pairs with Long Alignment Regions (>275 bp) According to Orientation, Separation Distance, and Sequence Identity

Orientation of paired Alus Distance between aligned regions (b + c) (bp) Frequency of Alupairs
degree of identity between pairedAlus
91%–100% (No.) 81%–90% (%) 71%–80% (%) 60%–70% (%)
Inverted
 DC 0–20 (0) 1.0 2.6 3.6
 Total: 5786 21–40 (1) 3.0 4.2 4.3
41–60 (0) 3.3 4.6 5.0
61–80 (0) 3.6 4.0 5.1
81–100 (2) 2.7 4.3 4.8
>100 (6) 86.3 80.4 77.3
(Total) (9) (1916) (3255) (606)
 CD 0–20 (0) 0.1 0.5 0.5
 Total: 5948 21–40 (0) 7.6 7.5 9.3
41–60 (2) 4.4 4.8 6.8
61–80 (0) 3.5 5.2 5.1
81–100 (1) 3.8 3.5 5.0
>100 (4) 80.6 78.5 73.5
(Total) (7) (1996) (3354) (591)
Direct
 (DD + CC) 0–20 (11) 24.3 22.2 20.9
 Total: 18,253 21–40 (3) 7.4 8.3 9.3
41–60 (2) 3.9 3.8 4.7
61–80 (2) 3.3 3.6 3.4
81–100 (1) 2.9 3.2 4.0
>100 (18) 58.3 58.9 57.8
(Total) (37) (6205) (10,251) (1760)

This Article

  1. Genome Res. 11: 12-27

Preprint Server