Identifying Potential Tumor Markers and Antigens by Database Mining and Rapid Expression Screening

Table 1.

Human Gene Expression Databases

Web site URL Tissues Description
ArrayExpress Database www.ebi.ac.uk/arrayexpress Pending Planned public repository of microarray data
Body Map bodymap.ims.u-tokyo.ac.jp Various normal and tumor Based on EST sequencing of ∼3000 reads each from 60 tissues
Brown Lab cmgm.stanford.edu/pbrown Cultured fibroblasts and B-cell lymphoma Custom cDNA array data and supplemental information
CGAP cDNA xProfiler www.ncbi.nlm.nih. gov/ncicgap/cgapxpsetup.cgi Most normal and tumor tissues Can search for cDNA library specific transcripts based on EST sequencing; most extensive profile
CGAP SAGEmap www.ncbi.nlm.nih.gov/SAGE Brain, colon ovary, prostate and breast; tumor and normal Ongoing SAGE expression analysis of cancer; ∼50,000 tags from each of 68 tissues and cell lines
Developmental Therapeutics www.dtp.nci.nih.gov NCI panel of 60 cancer cell lines Microarray and drug response data for NCI60 cell lines
Gene Expression Omnibus (GEO) www.ncbi.nlm.nih.gov/geo Pending Future public repository and comparison interface for all types of expression data
Human Gene Expression Index (HuGE) www.hugeindex.org Normal blood, kidney, cervix and vulva Affymetrix chip based database, expanding to cover many normal tissues
Prostate Expression Database chroma.mbt.washington.edu/PEDB Prostate normal, premalignant, and cancer Expression based on 60,000 ESTs in an easily queried interface
SAGEnet (Kinzler-Vogelstein Lab) www.sagenet.org Normal colon, colon, and pancreas cancer Over 400,000 SAGE transcript tags in downloadable files for local analysis
Genexpress-CNRS idefix.upr420.vjf.cnrs.fr/EXPR/ Brain, muscle, and other normals 5058 brain- or muscle-derived genes probed by filter array
TIGR Human Gene Index www.tigr.org/tdb/hgi/hgi.html Most normal tissues Has query interface for tissue-specific ESTs
Whitehead/MIT Genome Center's Molecular Pattern Recognition Web site waldo.wi.mit.edu/MPR Leukemias and hematopoeitic cell lines Affymetrix based array data available for download

This Article

  1. Genome Res. 10: 1393-1402

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