Predicting Protein Function by Genomic Context: Quantitative Evaluation and Qualitative Inferences

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 4.
Figure 4.

Domain organization of two proteins that are encoded by neighboring genes on B. subtilis (ymdA and ymdB) andB. burgdorferi (BB0504 and BB0505), and that are both present in M. genitalium (MG130 and MG246). The three domains that have functionally been characterized, KH, HD, and 5′NT, can all be related to ribonucleotide metabolism. KH binds (single-stranded) RNA; HD hydrolyzes phosphates from nucleotides; and 5′NT hydrolyzes NMP to nucleosides. A fourth, uncharacterized sequence domain (DUF) is present at C-terminus of MG246 and its orthologs.

This Article

  1. Genome Res. 10: 1204-1210

Preprint Server



Current Issue

  1. February 2026, 36 (2)
  1. Current Issue
  1. Alert me to new issues of Genome Research