High-resolution Genetic and Physical Map of the Lgn1 Interval in C57BL/6J Implicates Naip2 or Naip5 in Legionella pneumophila Pathogenesis

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Figure 8.
Figure 8.

Comparative map of Naip array in mice of the 129 and C57BL/6J haplotypes. A summary of physical maps constructed in two different inbred mouse strains is indicated. Conserved gene loci are indicated by common colors. Repeat microsatellite markers identify a quadruplication in mice of the 129 lineage and a duplication in the C57BL/6J haplotype. Gray shading indicates the two complete and two partial Naiploci specific to the 129 haplotype. A hypothetical insertion point between Naip5 and ΔNaip in the C57BL/6J haplotype is indicated (see Discussion). The genetically mapped Lgn1interval is indicated in the C57BL/6J haplotype. Two open boxes indicate the positions of two recombination hot spots identified in ourLgn1 backcross.

This Article

  1. Genome Res. 10: 1158-1171

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