Molecular Cloning, Genomic Organization, Developmental Regulation, and a Knock-out Mutant of a Novel Leu-rich Repeats-containing G Protein-coupled Receptor (DLGR-2) from Drosophila melanogaster

The sequence of each of the intron-exon boundaries is shown, as well as the codons for the amino acid residues. Uppercase and lowercase letters represent nucleotides in the exons and introns, respectively. For intron 1, the four splicing variants that we have isolated are given. These variants differ from each other, depending on which 5′ donor and 3′ acceptor sites are used. The sequences of the introns are given in our GenBank/EMBL Database submission. The overall positions of the introns are shown in Figs. 1 and 2. Introns 9-12 occur at the same positions within the gene and have the same intron phasing as four introns in the genes of the mammalian glycoprotein hormone receptors (• in Fig. 3).