Patterns of Variant Polyadenylation Signal Usage in Human Genes

Table 3.

Most Significant Hexamers in 3′ Fragments: Scattered Hexamers

Hexamer Observed (expected) % sites P Position average ± SD   Location
graphic 62 (10) 1.1 9 × 10−28 −19 ± 11 graphic
49 (10) 0.8 4 × 10−18 −20 ± 10
69 (20) 1.2 3 × 10−18 −17 ± 12
29 (5) 0.5 8 × 10−12 −20 ± 10
22 (3) 0.3 9 × 10−12 −24 ± 13
  • Expected occurrences based on a random distribution in a database of same nucleotide composition.

  • Probability of reaching the observed frequency by chance based on a cumulative binomial distribution. All sequences containing the most significant hexamer were removed from the database before the next most significant hexamer was sought.

  • Location of the last base of hexamer. Position 0 is the putative poly(A) site.

This Article

  1. Genome Res. 10: 1001-1010

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