Nature and Structure of Human Genes that Generate Retropseudogenes

Table 2.

Average Nonsynonymous (Ka) and Synonymous (Ks) Substitution Rate in Orthologous Genes Between Human and Murids According to their Number of Pseudogenes

No. of retropseudogenes Ka Ks Ks_nd
0 (n = 349) 0.109 ± 0.095 0.519 ± 0.149 0.396 ± 0.103
1 (n = 96) 0.044 ± 0.063 0.470 ± 0.241 0.421 ± 0.236
2 (n = 22) 0.022 ± 0.042 0.470 ± 0.134 0.436 ± 0.099
≥3 (n = 13) 0.026 ± 0.045 0.437 ± 0.135 0.399 ± 0.13
  • Rate according to no. of pseudogenes = mean value ±s.d. Ks_nd:Ks computed after removing doublet substitutions (see Duret and Mouchiroud 2000). The number of genes is indicated for each sample.

This Article

  1. Genome Res. 10: 672-678

Preprint Server