Null Mutation of PCLN-1/Claudin-16 Results in Bovine Chronic Interstitial Nephritis

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Figure 3.Figure 3.
Figure 3.

(a) DNA-based PCR test for CINF-carrier cattle. Reverse primers were designed for the deletion point. PCR primers DN-F and DN-R are for the normal allele (375 bp), and PCR primers DA-F and DA-R are for the mutant allele (722 bp). (b) Detection of the CINF mutant allele. (Lanes 1,2) Normal; (lanes 3,4) CINF carrier; (lanes 5,6) CINF-affected cattle; (lane 7) no DNA template as negative control. (M) size standard.

This Article

  1. Genome Res. 10: 659-663

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