Null Mutation of PCLN-1/Claudin-16 Results in Bovine Chronic Interstitial Nephritis

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Figure 2.Figure 2.
Figure 2.

(a) Alignment of CL-16 and PCLN-1. (Asterisks) Amino acid similarity; (shaded amino acids) highly conserved residues among claudin family members; (TM1–TM4), putative transmembrane domains. (b) Kidney-specific expression ofCL-16 in cattle. (Lane 1) Kidney; (lane 2) heart; (lane 3) lung; (lane 4) liver; (lane5) brain; (lane 6) muscle; (lane 7) kidney; (lane 8) CINF-affected kidney. (Arrow) Position of the 2.9-kbCL-16 transcript. (Bottom) Control glycerol-3-phosphate dehydrogenase expression.

This Article

  1. Genome Res. 10: 659-663

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