Association Between Nuclear Lamin A/C R482Q Mutation and Partial Lipodystrophy with Hyperinsulinemia, Dyslipidemia, Hypertension, and Diabetes

Table 2.

Summary of P-Values of Pairwise Comparisons

Q482/R482 Q482/R482 with diabetes vs.Q482/R482 without diabetes
with diabetes vs. R482/R482 without diabetes vs. R482/R482
Definite FPLD (%) 0.0000004 0.000000008 N.S.
Age (years) 0.047 N.S. 0.026
BMI (kg/m2) N.S. N.S. N.S.
Cholesterol (mmol/liter)
 total N.S. N.S. N.S.
 LDL N.S. N.S. N.S.
 HDL 0.0003 0.0038 0.0081
Triglycerides (mmoles/liter) 0.0007 0.011 0.022
Insulin (U/liter) 0.0056 0.0027 N.S.
C-peptide (pmoles/liter) 0.0014 0.0017 N.S.
Glucose (mmoles/liter) 0.003 N.S. 0.01
Hemoglobin A1C (%) 0.0003 N.S. 0.0017
Medication use
 hypertension (%) 0.025 N.S. 0.04
 dyslipidemia (%) N.S. N.S. N.S.
  • Comparisons are from Table 1.

  • (N.S.) Not significant.

This Article

  1. Genome Res. 10: 652-658

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