Structure of the Highly Conserved HERC2 Gene and of Multiple Partially Duplicated Paralogs in Human

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Figure 3.
Figure 3.

Identification of an evolutionary highly conserved Drosophila HERC2 gene. (a) Zooblot analysis of HERC2. A15 is a mouse–human somatic cell hybrid of which the only retained human chromosome is chromosome 15. (Monkey) African green monkey; (marsupial)Sminthopsis macroura. Arrows or arrowheads indicate bands in A15 that are of mouse or human origin, respectively. (Lanes1–3) A 3-day autoradiograph exposure; (lanes 4–10) a 7-day exposure. (b) Amino acid sequence comparison of the carboxy-terminal 762 residues of human HERC2 with the partialDrosophila HERC2 (743 residues). Asterisks (*) indicate identical residues.

This Article

  1. Genome Res. 10: 319-329

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