A Phenotype Map of the Mouse X Chromosome: Models for Human X-linked Disease
Abstract
The identification of many of the transcribed genes in man and mouse is being achieved by large scale sequencing of expressed sequence tags (ESTs). Attention is now being turned to elucidating gene function and many laboratories are looking to the mouse as a model system for this phase of the genome project. Mouse mutants have long been used as a means of investigating gene function and disease pathogenesis, and recently, several large mutagenesis programs have been initiated to fulfill the burgeoning demand of functional genomics research. Nevertheless, there is a substantial existing mouse mutant resource that can be used immediately. This review summarizes the available information about the loci encoding X-linked phenotypic mutants and variants, including 40 classical mutants and 40 that have arisen from gene targeting.
Footnotes
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Present addresses: 1Institute for Animal Health, Compton, Newbury RG20 7NN, UK; 2Department of Physiological Sciences, Medical School, Framlington Place, University of Newcastle, Newcastle Upon Tyne NE2 4HH, UK; 3Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK.
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↵4 Corresponding author.
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E-MAIL yvonne.boyd{at}bbsrc.ac.uk; FAX 00 44 1635 577237.
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↵5 A comprehensive list of international mouse strain resources, developed jointly by the UK MRC laboratory at Harwell and the USA Jackson Laboratory (Eppig and Strivens 1999), and a list of strains available at the newly established European Mouse Mutant Archive (EMMA) in Italy, can be accessed via the World Wide Web athttp://ismr.har.mrc.ac.uk; http://www.emma.cnr.it.
