Genetic Profile of Insertion Mutations in Mouse Leukemias and Lymphomas

Table 2.

Strain-Specific Mutation Profile

Common site Gene Map location Insertion frequency (%)
AKXD-10 AKXD13 AKXD-18 AKXD-27
Lvis1 Hex, Eg5 19 (26) 0 11 14 5
Lvis2 unknown  7 0 0 5 2
Lvis3 unknown 13 0 0 5 0
Lvis4 unknown 12 1/4 0 0 2
Lvis5 Alx4  2 (65) 0 0 2 2
Lvis6 Hex 19 (26) 0 0 0 5
Lvis7 Rel 11 (13) 0 0 0 5
Lvis8 CcnD3 17 0 0 0 2
Lvis9 Sox4 13 0 0 0 2
Evi3 Evi3 18 (5) 0 0 0 20
N-myc N-myc 12 (4) 0 0 5 2
Gfi1 Gfi1  5 (56) 0 0 0 2
Myc Myc 15 (32) 0 0 2 0
Notch1 Notch1  2 (15) 0 6 0 0

  • ↵Mouse chromosomal map locations either were determined in our laboratory or are based on published data. Primary mapping data are available from the Mouse Genome Informatics database (http://informatics.jax.org). Numbers in parentheses represent estimated distance from the centromere in centimorgans as assigned by MGD.

  • ↵Insertion frequency is calculated from a total of 18 AKXD-13 tumors, 42 AKXD-18 tumors and 41 AKXD-27 tumors, where the AKXD-10 frequency is shown as a fraction due to the number of tumors analyzed (4).

  • ↵Map locations determined using an (SB/Le × M. spretus)F1 × SB/Le interspecific backcross (Justice et al. 1990).

This Article

  1. Genome Res. 10: 237-243

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