Functional Classification of cNMP-binding Proteins and Nucleotide Cyclases with Implications for Novel Regulatory Pathways in Mycobacterium tuberculosis

Phylogenetic tree of 60 nucleotide cyclases from our superfamily. All branch lengths were made equal. Cyclases included in the tree are represented by their SwissProt designations; those proteins without a SwissProt name were given a similar designation in lower case, and are as follows: cya9_human is gi‖3138932, cygg_rat is gi‖2833642, cya_xenla is gi‖1514669, cyg_oryla is gi‖1838916, cyg3_manse is gi‖3511175, cya1_mycle is gi‖3097240, cya2_mycle is gi‖3150100, cya_syny3 is gi‖1652963, cya_trepa is gi‖3322767, except for theM. tuberculosis proteins, which are represented by their respective Rv designations.