Table 4.
List of Tags Corresponding to Ribosomal Protein Genes with Statistically Significant Differences between Normal and Is65Dn Male Brain SAGE Library
| Description | TAG | Normal males | Trisomic males | P | Normal females | 3T3 (Nor50K) | |||||||||
| Ribosomal protein L26 | T | G | G | G | C | A | T | C | C | A | 41 | 12 | 0.0000 | 26 | 0 |
| Ribosomal protein L5 | C | T | G | C | T | A | T | C | C | G | 32 | 9 | 0.0003 | 19 | 40 |
| Ribosomal protein S8 | T | G | T | A | G | T | G | T | A | A | 0 | 8 | 0.0035 | 6 | 12 |
| Ribosomal protein S6 | G | C | A | G | A | G | T | G | C | G | 14 | 32 | 0.0044 | 19 | 85 |
| Ribosomal protein S3 | C | C | C | C | A | G | C | C | A | G | 48 | 25 | 0.0065 | 42 | 156 |
| Ribosomal protein S19 | A | C | C | A | A | G | A | T | C | T | 13 | 3 | 0.0112 | 17 | 46 |
| ESTS, highly similar to 60S RIBOSOMAL PROTEIN L37 (Homo sapiens; Rattus norvegicus) | G | A | T | T | C | C | G | T | G | A | 64 | 39 | 0.0113 | 67 | 108 |
| Ribosomal protein S24 | G | C | C | T | T | T | A | T | G | A | 27 | 12 | 0.0155 | 30 | 43 |
| Ribosomal protein S7 | T | T | C | A | G | C | T | C | G | A | 19 | 33 | 0.0303 | 38 | 44 |
| ESTs, weakly similar to Bacillus stearothermophilus 30S ribosomal protein S21 (Caenorhabditis elegans) | T | C | C | A | A | C | T | C | C | T | 1 | 7 | 0.0327 | 7 | 2 |
| EST, weakly similar to 60S ACIDIC RIBOSOMAL PROTEIN P2 (Rattus norvegicus) | G | G | A | T | T | T | G | G | C | T | 66 | 45 | 0.0388 | 78 | 44 |
| Ribosomal protein s14 | T | T | G | G | C | T | G | C | C | C | 28 | 43 | 0.0422 | 40 | 73 |
| Ribosomal protein L30 | C | C | A | G | A | A | C | A | G | A | 26 | 14 | 0.0464 | 23 | 68 |
| Ribosomal protein L37a | A | A | A | A | C | A | G | T | G | F | 27 | 15 | 0.0489 | 35 | 36 |
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The identity for each tag (Description) and statistical significance (P) of observed differences between normal and Ts65Dn SAGE libraries are presented. The number of tags in SAGE libraries derived from normal (Normal males) or Ts65Dn (Trisomic males) mouse male brains, normal female brains (Normal females), and mouse embryonic cell line 3T3 are shown. Tags from the 3T3 SAGE library were normalized for a total of 50,000.
