The Mouse Brain Transcriptome by SAGE: Differences in Gene Expression between P30 Brains of the Partial Trisomy 16 Mouse Model of Down Syndrome (Ts65Dn) and Normals

Table 2.

Comparison of the 15 Most Expressed Tags in the Mouse Brain Transcriptome

TAG sequence Mouse UniGene no. pA signal Human UniGene no. Mouse gene description No. of mice TAGs No. of human TAGs
G T G G C T C A C A 4184 Yes Multiple matches 2626
G C T T C G T C C A 2992 Yes 69547 Myelin basic protein 1013 261
A G C A G T C C C C 3776 No TAG matches mitochondrial sequence 870
T C A G G C T G C C 1776 Yes 62954 Ferritin heavy chain 573 440
G C A C A A C T T G 18041 No Multiple matches 554
G T G A C C T G G C 1008 Yes 8272 Prostaglandin D2 synthase (21 kD, brain) 496 282
G C C T C C A A G G 5289 Yes 195188 Glyceraldehyde-3-phosphate dehydrogenase 490 302
A A A A A A A A A A 15295 Yes Multiple matches 481
G A G C G T T T T G 5246 Yes 182937 Peptidyl-prolycis-trans isomerase A 475 142
C A A A C C T C C A 28177 No TAG matches mitochondrial sequence 400
C A T C G C C A G T 21417 Yes 169401 Apolipoprotein E 397 191
A G C A A T T C A A 30071 No TAG matches mitochondrial sequence 390
A A T T C G C G G A No match 375
C C T T G C T C A A 43036 Yes 135084 Cystatin C 347 274
T G A C C C C G G G 43766 Yes Ubiquitin/60s ribosomal fusion protein 333
  • The corresponding mRNA to each tag has been determined when possible. The human homolog for most of these was determined using UniGene searches. For each mouse tag sequence the numbers of detected copies in ∼150,000 tags from mouse brain SAGE libraries (No. of mice tags) are shown. The presence of polyadenylation signal in the corresponding mouse UniGene entry (Mouse UniGene no.) was noted (pA signal). The corresponding human transcript was obtained from the human UniGene library (Human UniGene no.) and the number of tags representing this transcript in 150,000 tags from human brain SAGE library was determined (No. of human tags). Mouse transcripts with known poly(A) signal for which the homolog was detected in the human brain transcriptome are shaded in gray.

This Article

  1. Genome Res. 10: 2006-2021

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