Single QTL Effects, Epistasis, and Pleiotropy Account for Two-thirds of the Phenotypic F2 Variance of Growth and Obesity in DU6i x DBA/2 Mice

Table 8.

Joint Effect of the Identified QTLs and Locus*Locus Interactions

Trait Joint net effect of QTLs (%) Joint net effect of interaction (%) Joint net effect of QTLs and interaction together(%)
BW 34.9 32.9 64.4
AFW 34.1 35.5 62.8
AFP 26.2 n.d. n.d.
MW 27.9 20.7 31.8
LW 31.3 n.d. n.d.
KW 16.9 n.d. n.d.
SW 17.3 n.d. n.d.
Leptin 24.0 29.9 44.5
Insulin 9.1 20.3 21.2
IGF-I 22.5 32.8 41.6
  • The net effect is given as reduction of the residual sum of squares with and without inclusion of all QTLs, all interactions, or all QTLs and interactions together in the analysis.

  • The estimates for the joined net effect of all QTLs result from multipoint linkage analysis using the most likely QTL position.

  • The estimates for the joined net effect of interaction and of QTLs and interaction together result from the analysis using the marker positions next to the most likely QTL positions found via linkage analysis.

This Article

  1. Genome Res. 10: 1941-1957

Preprint Server