Role of Members of the Serpin Superfamily
| Serpin | Abbreviation | Role | Primary function/target | References | Species |
| α1-Antichymotrypsin | ACT | In | chymotrypsin | a | M |
| α1-Antitrypsin | AAT | In | elastase | b | M/Am |
| α2-Antiplasmin | A2AP | In | plasmin | c | M |
| Accessory gland protein | Acp76A | O | reproductive system | d | dme |
| Angiotensinogen | ANGT | O | non-inhibitory, hormone precursor | e,f | M |
| Antithrombin | ANT | In/O | thrombin, factor Xa, anti-angiogenesis | g,h | M/F |
| Blood fluke serpins | Ac | N | inhibitory RCL, target unknown.Schistosoma haematobium major antigen | i | sma/ja/ha |
| Bomapin | Bomapin | In | inhibitory activity vs serine proteinases | j | hsa |
| Bombyx moriserpins | Ac | In, N | inhibitory activity vs serine proteinases | k | bmo |
| C1 inhibitor | C1-I | In | complement C1 esterase | l | M |
| Corticosteroid-binding globulin | CBG | O | non-inhibitory, hormone binding | m | M/Am |
| Factor Xa–directed anticoagulant | Ac | In | reversible noncovalent factor Xa inhibition | n | aae |
| Glia-derived nexin | GDN | O/In | neurite outgrowth, thrombin | o | M |
| Heat shock protein 47 | HSP47 | O | chaperone, folding, collagen processing | p | M/F |
| Heparin cofactor II | HEPII | In | thrombin/chymotrypsin | q,r | M/Am |
| Kallistatin | KAL | In | tissue kallikrein | s | M |
| Limulus intracellular coagulation inhibitor | LICI | In | factor C, limulus clotting enzyme, other serine proteases | t | ttr |
| Manduca sextaalaserpin (12 splice variants) | SERP-1 | In, N | some show inhibitory activity vs serine proteinases | u | mse |
| Maspin | Maspin | In | tissue-type plasminogen activator/prevents metastasis | v,w | M |
| Monocyte/neutrophil elastase inhibitor | MNEI | In | proteinase 3, cathepsin G | x | M |
| Myeloid and erythroid nuclear-termination stage specific protein | MENT | O | chromatin condensation | y | gga |
| Nematode | Ac | N | many with inhibitory RCL, targets unknown | z | cel |
| Neuroserpin | NEUS | In | plasminogen activator, urokinase, plasmin | aa | M |
| Ovalbumin | OVAL | N | non-inhibitory | bb,cc | A |
| PI6 | PI6 | In | cathepsin G | dd | M |
| PI8 | PI8 | In | trypsin-like proteinases | ee,ff | hsa |
| PI9 | PI9 | In | granzyme B | gg | M |
| Pigment epithelium-derived factor | PEDF | O | neurotrophic factor | hh | M |
| Plant serpins (e.g., protein Z) | Ac | In | inhibitory activity vs serine proteinase, target unknown | ii,jj | P |
| Plasminogen Activator Inhibitor-1 | PAI-1 | In | tissue-type plasminogen activator | kk | M |
| Plasminogen Activator Inhibitor-2 | PAI-2 | In | tissue-type plasminogen activator, intracellular signaling | ll,mm | M |
| Protein C Inhibitor | PCI | In | protein C | nn | M |
| Regeneration-Associated Protein | RASP-1 | In | liver regeneration, human homolog protein Z potent FXa inhibitor | oo | rno |
| Sea lamprey serpin | Ac | N | inhibitory RCL, target unknown | pp | pma |
| Signal crayfish | Ac | N | inhibitory RCL, target-unknown | ple | |
| Squamous Cell Carcinoma Antigen-1 | SCCA-1 | In | inhibitory activity vs papain-like cysteine proteases | rr | hsa |
| Squamous Cell Carcinoma Antigen-2 | SCCA-2 | In | inhibitory activity vs serine proteinases | ss | M |
| Thyroxine-binding globulin | TBG | O | non-inhibitory, hormone binding | tt | M/Am |
| TP55 | Megsin | O | megakaryocyte maturation | uu | hsa |
| Uterine milk protein | UTMP | In/O | activin binding, inhibitory activity vs aspartic proteases | vv,ww | M |
| Viral serpin CrmA | CrmA | In | interleukin-converting enzyme 1β | xx | V |
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(Ac) Identified by its individual accession.
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↵(In) Protease inhibitor; (O) other function; (N) not known.
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↵Where sequences are present in more than one species, the class is given. (A) avian; (Am) amphibian; (F) fish; (M) mammalian; (P) plant; (V) viral. Italicized labels refer to individual species: (aae) Aedes aegypti; (bmo)Bombyx mori; (cel) Caenorhabditis elegans; (dme) Drosophila melanogaster;(gga) Gallus gallus; (hsa) Homo sapiens; (mse) Manduca sexta;(ple) Pacifastacus leniusculus; (pma)Petromyzon marinus; (rno) Rattus norvegicus; (sma/ja/ha). Schistosoma mansoni, Schistosoma japonicum, Schistosoma haematobium; (ttr)Tachypleus tridentatus.
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Kalsheker 1996 (review); b Patterson 1991 (review);c Holmes et al. 1987; d Wolfner et al. 1997;e Stein et al. 1989; f Arakawa et al. 1965;g O'Reilly et al. 1999; h Lane et al. 1992 (review);i Blanton et al. 1994; j Riewald and Schleef 1995;k Sasaki 1991; l Zeerleder et al. 1999 (review);m Pemberton et al. 1988; n Stark and James 1998;o Zurn et al. 1988; p Nakai et al. 1992;q Tollefsen et al. 1982; r Church et al. 1985;s Wang et al. 1989; t Miura et al. 1994;u Jiang and Kanost 1997; v Sheng et al. 1998;w Zou et al. 1994; x Sugimori et al. 1995;y Grigoryev et al. 1992; z Whisstock et al. 1999;aa Krueger et al. 1997; bb Wright 1984;cc Stein et al. 1989; dd Scott et al. 1999a;ee Sprecher et al. 1995; ff Dahlen et al. 1998;gg Bird et al. 1998; hh Steele et al. 1993;ii Lundgard and Svensson 1989; jj Rasmussen et al. 1996; kk Reilly et al. 1994 (review); ll Dickinson et al. 1998; mm Astedt et al. 1998 (review); nn Suzuki et al. 1983; oo New et al. 1996; pp Robson et al. 1998; qq Liang and Soderhall 1995; rr Schick et al. 1998; ss Schick et al. 1998; tt Pemberton et al. 1988; uu Tsujimoto et al. 1997; vv McFarlane et al. 1999; ww Mathialagan and Hansen 1996; xx Ray et al. 1992.
