Phylogeny of the Serpin Superfamily: Implications of Patterns of Amino Acid Conservation for Structure and Function

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Figure 6.
Figure 6.

PAI-1 (black) has a Gln at a position 334 in the shutter that makes a hydrogen bond to P10 Ser in the reactive center loop (RCL). The consensus residue (e.g., in antithrombin [red]) at position 334 is a His that makes a hydrogen bond to P8 Thr (blue) in the RCL.

This Article

  1. Published in Advance November 21, 2000, doi: 10.1101/gr.147800 Genome Res. 10: 1845-1864

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