Comparison of the imprinted IGF2/H19 domain on chromosome 11p15.5 with the DLK1/GTL2 domain on chromosome 14q32. Physical distances are indicated at the top of the diagram. CTCF binding sites are indicated as shaded vertical rectangles, and black circles indicate the positions of enhancer elements. Differentially methylated regions (DMR) are indicated.G1, G2, and G3 are shown as black bars and correspond to the three areas analyzed for differential methylation (Figs. 3 A,B). The position of the telomere (t) is shown relative to each imprinted domain. The transcription units for each gene are shown as boxes, and the direction of transcription for maternally and paternally expressed genes is denoted by arrows above and below the boxes.
